During the Portuguese rule on Goa Jesuits missionaries had constructed this one of best illustration of the Indian Baroque style Church building in India in the year 1564. The original church was damaged during the Muslim invasion of Salcete in 1571.

Rebuilding of The Holy Spirit Church, consists of a pristine white outer facade and towers on either side with a central dome structure, was started in 1645 and after 30 years the church was consecrated in 1675.

In the recent times celebration of feast generates cherish environment of fair and carnival and become one of the pre monsoon shopping opportunity for the natives. People from all parts of beach state Goa visit Margao during these 5-6 days and shop for dry fish, household items, spices, furniture, and many other household items. Bright - orange 'sweet-meet' sold on the stalls erected on the open space opposite to church is the signatory food stuff of feast of the Holy Spirit Church of Margao.